INFO 1 of 2: The Impact of Environmental Toxins on Health & Aging

From: Quicksilver Scientific - Friday Nov 11,2022 12:54 am

Dear Leslie,

The WHO recognizes that at least 24% of the global chronic disease burden is due to preventable environmental factors, including toxin exposure.1 More and more studies are surfacing that correlate a high toxic burden with accelerated aging. In fact, researchers are using the term 'gerontogens' to define the toxicology of aging and its effects on multiple body systems. As the term carcinogens has proven crucial to modern cancer biology, the continued study of toxicants and their effects on aging will help improve how we assess and treat our patients now and in the future. In this two-part email series, we highlight multiple studies to show the far-ranging effects that environmental toxins have on health and aging. Today, we’re sharing data on toxins and their impact on mitochondria, cardiovascular and immune systems.

Toxins + Mitochondria Environmental toxins can compromise mitochondrial function by inhibiting the mitochondrial electron transport chain (ETC), uncoupling oxidative phosphorylation, and reducing mitochondrial antioxidant capacity.2 Inhibition of these mitochondrial elements has been shown to impair ATP generation, creating downstream effects on aspects of metabolism, including insulin sensitivity.3 Toxins + Cardiovascular System Research indicates that fine particulate matter (PM2.5) may promote atherosclerosis by damaging the vascular endothelium, the single layer of cells that constitutes the inner cellular lining of arteries, veins, and capillaries.4 PM2.5 refers to particulate matter with a diameter of less than 2.5 μm and is derived primarily from the combustion of fossil fuels, diesel exhaust, and indoor cooking activities.5 Toxins + Immune System Toxins degrade and dysregulate the immune system through multiple mechanisms. For example, mycotoxins can suppress innate and acquired immunity, immobilizing critical immune defenses effectively distracting the immune system from more pressing threats.6 Chemical plasticizers, including BPA and phthalates, also demonstrate harmful effects on immune function. For example, during fetal development, BPA exposure induces epigenetic and cell signaling changes in branches of the immune system that have been shown to drive a host of immune-dysregulation problems.7

The data shows: the more exposure and accumulation of toxins in the body, the greater the likelihood of those toxins exerting a dangerous combination of effects to long-term health. Join us at our next webinar:

UPCOMING WEBINAR Quicksilver's Detoxification Protocols. How and When to Use. How to Individualize and Optimize. November 16th. Click To Register

REFERENCES 1. Pruss-Ustun A and Corvalan C. How much disease burden can be prevented by environmental interventions? Epidemiol. 2007; 18(1): 167-178. 2. Zolkipli-Cunningham Z and Falk MJ. Clinical effects of chemical exposures on mitochondrial function. Toxicology. 2017; 391: 90-99. 3. Sangwung P et al. Mitochondrial dysfunction, insulin resistance, and potential genetic implications. Endocrinol. 2020; 161(4): bqaa017. 4. Janssen JAMJL. Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease, and cancer. Int J Mol Sci. 2021; 22(15): 7797. 5. Liang S et al. The critical role of endothelial function in fine particulate mater-induced atherosclerosis. Part Fibre Toxicol. 2020; 17(61). 6. Liang CS et al. Review on recent progress in observations, source identifications and countermeasures of PM2.5. Environ Int. 2016; 86: 150-170. 7. Davignon J and Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004. 109: III-27-III-32.

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