NAD+: A Fountain of Youth Molecule?

From: Quicksilver Scientific - Tuesday Apr 25,2023 01:17 am

What You Need to Know About the Molecule NAD+

NAD+ (nicotinamide adenine dinucleotide) is a molecule that is naturally present in every cell of the body and is critical for DNA repair, cellular bioenergetics, genomic signaling, and cell survival.(1,2) As a carrier of high-energy electrons, NAD+ helps drive mitochondrial oxidative phosphorylation, the process by which cells oxidize nutrients to produce ATP. NAD+ is also a crucial cofactor for sirtuins, a family of seven proteins that play regulatory roles in energy metabolism, mitochondrial function, and stress resistance, thereby influencing the aging process. Together, this confluence of effects means that NAD+ significantly supports the aging process.(3) NAD+ levels naturally decline with age. One reason for this decline is that CD38, a glycoprotein found on the surface of immune cells, “gobbles up” NAD+ at an accelerated rate as part of the low-level inflammatory process that manifests as we age.(4)

NAD+: A Fountain of Youth Molecule? As we age we experience a steady decrease in NAD+ biosynthesis and a corresponding functional decline in organs and tissues, all a part of the aging process.(5),(6) In fact, by middle age, our NAD+ levels have plummeted to half that of our youth.(7) Because of this, NAD+ repletion has become a mainstay in regenerative medicine and anti-aging circles. Here are a few reasons why practitioners are referring to NAD+ supplementation as the proverbial “Fountain of Youth”:

NAD+ is Required for Sirtuin Activation: Sirtuins are a family of seven proteins that help regulate numerous cellular functions, including inflammation, circadian rhythms, energy metabolism, and neuronal function.(8) The way sirtuins impact physiological processes is key to longevity. In order to activate sirtuins, cellular levels of NAD+ must be high. As well, plant compounds like resveratrol and quercetin are needed to help ensure their activation. You'll often see these supporting players referred to as Sirtuin Activating Compounds or STACs.

NAD+ Supports Mitochondrial Function and Biogenesis: Are you familiar with the Mitochondrial Theory of Aging? It considers aging as the result of an accumulation of damage to biomolecules due to the excessive production of highly toxic reactive oxygen species (ROS) by the mitochondria. As we age, mitochondria accumulate ROS-induced damage and become dysfunctional. NAD+ is an important component to supporting healthy functioning mitochondria as well as generating new mitochondria. To drive functioning mitochondria, these powerful organelles require NAD+ and NADH respectively as cofactors. Sirtuin activation is also a component when supporting mitochondrial metabolism and biogenesis. NAD+ supplementation has risen to the top as one of the most influential and foundational supplements for healthy aging. Are you supplementing your patients with NAD+?

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References:
(1,2) Interventions to Slow Aging in Humans: Are We Ready?
(3) It takes two to tango: NAD+ and sirtuins in aging/longevity control
(4) Why NAD+ Declines during Aging: It’s Destroyed
(5,6) The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control
(7) In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences
(8) Sirtuins Link Inflammation and Metabolism

*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

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