What Is The Best Way To Supplement NAD+?

From: Quicksilver Scientific - Wednesday Apr 26,2023 01:30 pm

Quicksilver Scientific®

What is the Best Way to Supplement NAD+?

As our understanding of NAD+’s importance for health and longevity has expanded, the scientific community has leaped into action, researching safe, efficacious ways to support the replenishment of cellular NAD+ levels. Scientists have identified a few molecules with NAD+ boosting effects; these compounds are referred to as “NAD+ boosters.” However, not all NAD+ boosters offer the same results. For example, nicotinic acid (NA) and nicotinamide (NAM) are two NAD+ precursor molecules that can be used to generate NAD+. However, the processes required to convert them into NAD+ are complicated and inefficient. Nicotinamide riboside (NR) is another NAD+ precursor that offers more therapeutic potential than NA and NAM. However, it must first be converted into NMN before transforming into NAD+. Nicotinamide mononucleotide (NMN) is a potent alternative to NA, NAM, and NR for supporting NAD+ production. It is a direct, stable NAD+ precursor that has been found to help NAD+ levels and may thus help alleviate the downstream health impacts of NAD+ depletion.1 You may ask, why not supplement with NAD+ directly? Unfortunately, direct supplementation with NAD+ is ineffective for increasing systemic NAD+ levels due to the molecule’s propensity to break down in the gut.

NMN: A Standout for NAD+ Supplementation It was originally thought that NMN was unable to enter cells on its own and that NR was the only precursor that could effectively raise NAD+ levels. However, in 2019, groundbreaking research showed that NMN has a unique and dedicated transporter (Slc12a8) that can move the molecule quickly across the cell membrane and into the cell where it can be transformed rapidly into NAD+.2

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References:
(1) Hong W, et al. Nicotinamide mononucleotide: A promising molecule for therapy of diverse diseases by targeting NAD+ metabolism. Front Cell Dev Biol. 2020.

(2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530925/

*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

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